InnateDB Protein
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IDBP-586007.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MTF2
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Protein Name
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metal response element binding transcription factor 2
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Synonyms
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dJ976O13.2; M96; PCL2; TDRD19A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000444962
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InnateDB Gene
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IDBG-100300 (MTF2)
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Protein Structure
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Function |
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0007379
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segment specification
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GO:0016568
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chromatin modification
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GO:0019827
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stem cell maintenance
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048863
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stem cell differentiation
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GO:0061086
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negative regulation of histone H3-K27 methylation
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GO:0061087
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positive regulation of histone H3-K27 methylation
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Cellular Component |
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PDB ID |
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InterPro |
IPR001965
Zinc finger, PHD-type
IPR011011
Zinc finger, FYVE/PHD-type
IPR019787
Zinc finger, PHD-finger
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PFAM |
PF00628
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PRINTS |
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PIRSF |
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SMART |
SM00249
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y483
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PhosphoSite |
PhosphoSite-Q9Y483
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TrEMBL |
B4DZG1
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UniProt Splice Variant |
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Entrez Gene |
22823
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UniGene |
Hs.743474
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RefSeq |
NP_001157863
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HUGO |
HGNC:29535
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OMIM |
609882
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CCDS |
CCDS53341
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HPRD |
14342
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IMGT |
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EMBL |
AC093577
AF072814
AF073293
AJ010014
AK290318
AK302900
AL117354
CH471097
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GenPept |
AAC27080
AAC27618
BAF83007
BAG64073
CAA08970
CAI23502
EAW73085
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