Version 5.4
Homo sapiens Gene: MTF2
Summary
InnateDB Gene IDBG-100300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTF2
Gene Name metal response element binding transcription factor 2
Synonyms dJ976O13.2; M96; PCL2; TDRD19A
Species Homo sapiens
Ensembl Gene ENSG00000143033
Encoded Proteins
IDBP-100304
metal response element binding transcription factor 2
IDBP-100308
metal response element binding transcription factor 2
IDBP-586007
metal response element binding transcription factor 2
IDBP-591640
metal response element binding transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:93079235-93139081
Strand Forward strand
Band p22.1
Transcripts
ENST00000370303 ENSP00000359326
ENST00000370298 ENSP00000359321
ENST00000474314
ENST00000473430
ENST00000494963
ENST00000471953
ENST00000467953
ENST00000497976
ENST00000468457
ENST00000476037
ENST00000487263
ENST00000489480
ENST00000545708 ENSP00000444962
ENST00000540243 ENSP00000443295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 19 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007379 segment specification
GO:0016568 chromatin modification
GO:0019827 stem cell maintenance
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048863 stem cell differentiation
GO:0061086 negative regulation of histone H3-K27 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029267
View Gene Order
ENSBTAG00000001393
Not yet available
Pathways
NETPATH
REACTOME
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.31016 Hs.604571 Hs.613142 Hs.712767 Hs.743474
RefSeq NM_001164391 NM_001164392 NM_001164393 NM_007358
HUGO
OMIM
CCDS CCDS53340 CCDS53341 CCDS742
HPRD 14342
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca