Version 5.4
Homo sapiens Protein: FCRL3
Summary
InnateDB Protein IDBP-586032.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCRL3
Protein Name Fc receptor-like 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000434331
InnateDB Gene IDBG-103681 (FCRL3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cell membrane {ECO:0000269PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269PubMed:16849395}.
Disease Associations Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269PubMed:15838509, ECO:0000269PubMed:16176992, ECO:0000269PubMed:16476711, ECO:0000269PubMed:16859508, ECO:0000269PubMed:17133579, ECO:0000269PubMed:17179172, ECO:0000269PubMed:17763442}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
Tissue Specificity Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level). {ECO:0000269PubMed:11493702, ECO:0000269PubMed:11929751, ECO:0000269PubMed:12051764, ECO:0000269PubMed:15838509, ECO:0000269PubMed:16849395}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin
PFAM PF00047
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P31
PhosphoSite PhosphoSite-Q96P31
TrEMBL R4GNJ6
UniProt Splice Variant
Entrez Gene 115352
UniGene Hs.733831
RefSeq XP_006711209
HUGO HGNC:18506
OMIM 606510
CCDS CCDS1167
HPRD 07352
IMGT
EMBL AF416901 AF416902 AF416903 AF416904 AF416905 AK098122 AL356276 AY043466 BC028933 CH471121 EF064732
GenPept AAH28933 AAK91779 AAL13290 AAL13291 AAL13292 AAL13293 AAL13294 ABK41915 CAH73055 CAH73056 CAH73058 EAW52872 EAW52876 EAW52877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca