InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCF2L

Summary

InnateDB Protein

IDBP-586035.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCF2L

Protein Name

MCF.2 cell line derived transforming sequence-like

Synonyms

ARHGEF14; DBS; OST;

Species

Homo sapiens

Ensembl Protein

ENSP00000440374

InnateDB Gene

IDBG-52007 (MCF2L)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42. {ECO:0000250, ECO:0000269PubMed:15157669}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005545	1-phosphatidylinositol binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001251 CRAL-TRIO domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR011511 Variant SH3 domain
IPR018159 Spectrin/alpha-actinin

PFAM