InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDYL

Summary

InnateDB Protein

IDBP-58617.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDYL

Protein Name

chromodomain protein, Y-like

Synonyms

CDYL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000340908

InnateDB Gene

IDBG-58613 (CDYL)

Protein Structure

UniProt Annotation

Function

Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4. {ECO:0000269PubMed:12072557, ECO:0000269PubMed:19061646, ECO:0000269PubMed:22009739}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18450745, ECO:0000269PubMed:19808672}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform. {ECO:0000269PubMed:19808672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0003824	catalytic activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0035064	methylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0016573	histone acetylation