Version 5.4
Homo sapiens Protein: RIC8B
Summary
InnateDB Protein IDBP-586174.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIC8B
Protein Name resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436359
InnateDB Gene IDBG-54957 (RIC8B)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. {ECO:0000250}.
Subcellular Localization Cytoplasm, cell cortex {ECO:0000269PubMed:12652642}. Note=Localizes to the cell cortex.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
Protein Structure and Domains
PDB ID
InterPro IPR008376 Synembryn
IPR019318 Guanine nucleotide exchange factor, Ric8
PFAM PF10165
PRINTS PR01802
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NVN3
PhosphoSite PhosphoSite-Q9NVN3
TrEMBL
UniProt Splice Variant
Entrez Gene 55188
UniGene Hs.607848
RefSeq
HUGO HGNC:25555
OMIM 609147
CCDS
HPRD 16452
IMGT
EMBL AC007695 AC079385 AC090011 AK001482 AK128102 AY221116 BC034220 BC132689 BC144056
GenPept AAH34220 AAI32690 AAI44057 AAO65923 BAA91717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca