InnateDB Protein
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IDBP-586369.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ANKLE2
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Protein Name
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ankyrin repeat and LEM domain containing 2
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Synonyms
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KIAA0692; Lem4; LEMD7;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000437807
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InnateDB Gene
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IDBG-65913 (ANKLE2)
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Protein Structure
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Function |
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. {ECO:0000269PubMed:22770216}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:22770216}; Single-pass type III membrane protein {ECO:0000269PubMed:22770216}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86XL3
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PhosphoSite |
PhosphoSite-Q86XL3
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TrEMBL |
F5H1D4
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UniProt Splice Variant |
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Entrez Gene |
23141
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UniGene |
Hs.666964
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RefSeq |
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HUGO |
HGNC:29101
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB014592
AC135586
AC136467
AK024061
AK093451
AK293028
BC001530
BC025347
BC043157
BC062373
BC082962
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GenPept |
AAH01530
AAH25347
AAH43157
AAH62373
AAH82962
BAA31667
BAF85717
BAG51259
BAG52720
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