Homo sapiens Protein: NOX4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-586795.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | NOX4 | ||||||||||||||||||
Protein Name | NADPH oxidase 4 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000436892 | ||||||||||||||||||
InnateDB Gene | IDBG-67316 (NOX4) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1. | ||||||||||||||||||
Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000305}. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.Isoform 4: Nucleus {ECO:0000269PubMed:23393389}. Nucleus, nucleolus {ECO:0000269PubMed:23393389}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells. {ECO:0000269PubMed:11032835, ECO:0000269PubMed:11376945, ECO:0000269PubMed:15210697, ECO:0000269PubMed:16324151}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR013112
FAD-binding 8 IPR013121 Ferric reductase, NAD binding IPR013130 Ferric reductase transmembrane component-like domain IPR017938 Riboflavin synthase-like beta-barrel |
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PFAM |
PF08022
PF08030 PF01794 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART | |||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9NPH5 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9NPH5 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 50507 | ||||||||||||||||||
UniGene | Hs.591995 | ||||||||||||||||||
RefSeq | NP_001137308 | ||||||||||||||||||
HUGO | HGNC:7891 | ||||||||||||||||||
OMIM | 605261 | ||||||||||||||||||
CCDS | CCDS44695 | ||||||||||||||||||
HPRD | 09243 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB041035 AF254621 AF261943 AJ704725 AJ704726 AJ704727 AJ704728 AJ704729 AK291830 AK298323 AP001815 AP002404 AP003400 AY288918 BC040105 BC051371 | ||||||||||||||||||
GenPept | AAF68973 AAF87572 AAH40105 AAH51371 AAP41109 BAA95695 BAF84519 BAH12756 CAG28807 CAG28808 CAG28809 CAG28810 CAG28811 | ||||||||||||||||||