InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP5C

Summary

InnateDB Protein

IDBP-58689.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP5C

Protein Name

protein phosphatase 5, catalytic subunit

Synonyms

PP5; PPP5; PPT;

Species

Homo sapiens

Ensembl Protein

ENSP00000012443

InnateDB Gene

IDBG-58687 (PPP5C)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. {ECO:0000269PubMed:14734805, ECO:0000269PubMed:14764652, ECO:0000269PubMed:14871926, ECO:0000269PubMed:15383005, ECO:0000269PubMed:15546861, ECO:0000269PubMed:16260606, ECO:0000269PubMed:16790549, ECO:0000269PubMed:16892053, ECO:0000269PubMed:19176521, ECO:0000269PubMed:19948726, ECO:0000269PubMed:21144835, ECO:0000269PubMed:22399290, ECO:0000269PubMed:22781750, ECO:0000269PubMed:23102700, ECO:0000269PubMed:9000529}.

Subcellular Localization

Nucleus. Cytoplasm. Membrane. Note=Predominantly nuclear. But also present in the cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15546861}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	72 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0008219	cell death
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278	response to morphine
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR011236 Serine/threonine protein phosphatase 5
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR013235 PPP domain
IPR019734 Tetratricopeptide repeat
IPR029052 Metallo-dependent phosphatase-like

PFAM