InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP5C

Summary

InnateDB Gene

IDBG-58687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP5C

Gene Name

protein phosphatase 5, catalytic subunit

Synonyms

PP5; PPP5; PPT

Species

Homo sapiens

Ensembl Gene

ENSG00000011485

Encoded Proteins

IDBP-58689

protein phosphatase 5, catalytic subunit

IDBP-246716

protein phosphatase 5, catalytic subunit

IDBP-588915

protein phosphatase 5, catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:46346994-46392981

Strand

Forward strand

Band

q13.32

Transcripts

ENST00000012443	ENSP00000012443
ENST00000391919	ENSP00000375786
ENST00000478046	ENSP00000434329
ENST00000467902
ENST00000486994
ENST00000493347
ENST00000487483
ENST00000491003
ENST00000492109
ENST00000467502
ENST00000527193
ENST00000532058
ENST00000525507
ENST00000527623
ENST00000595055

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	77 [view]
Protein-Protein	72 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0008219	cell death
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043278	response to morphine
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003099

View Gene Order

ENSBTAG00000008014

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

erbb1_downstream_pathway

ErbB1 downstream signaling

reg_gr_pathway

Glucocorticoid receptor regulatory network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.601993 Hs.654604 Hs.735375

RefSeq

NM_001204284 NM_006247

HUGO

OMIM

CCDS

CCDS12684

HPRD

02805

IMGT

EMBL

GenPept

RNA Seq Atlas