InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IPO8

Summary

InnateDB Protein

IDBP-586894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IPO8

Protein Name

importin 8

Synonyms

RANBP8;

Species

Homo sapiens

Ensembl Protein

ENSP00000444520

InnateDB Gene

IDBG-25343 (IPO8)

Protein Structure

UniProt Annotation

Function

Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO:0000269PubMed:11682607, ECO:0000269PubMed:9214382}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.