InnateDB Protein
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IDBP-586979.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPF3
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Protein Name
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D4, zinc and double PHD fingers, family 3
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Synonyms
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BAF45C; CERD4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441640
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InnateDB Gene
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IDBG-11119 (DPF3)
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Protein Structure
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Function |
Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. {ECO:0000250, ECO:0000269PubMed:18765789}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q92784
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PhosphoSite |
PhosphoSite-Q92784
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8110
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UniGene |
Hs.739794
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RefSeq |
NP_036206
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HUGO |
HGNC:17427
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OMIM |
601672
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CCDS |
CCDS45133
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HPRD |
03395
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IMGT |
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EMBL |
AC004828
AC006360
AK024141
AK126933
AL392024
AY803021
BC060801
U43919
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GenPept |
AAC50686
AAH60801
AAX20019
BAB14838
BAC86753
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