InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFIT1

Summary

InnateDB Protein

IDBP-587206.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFIT1

Protein Name

interferon-induced protein with tetratricopeptide repeats 1

Synonyms

C56; G10P1; IFI-56; IFI-56K; IFI56; IFIT-1; IFNAI1; ISG56; P56; RNM561;

Species

Homo sapiens

Ensembl Protein

ENSP00000441968

InnateDB Gene

IDBG-81960 (IFIT1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.

Experimentally validated
Total	58 [view]
Protein-Protein	49 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0009615	response to virus
GO:0019060	intracellular transport of viral protein in host cell
GO:0019221	cytokine-mediated signaling pathway
GO:0032091	negative regulation of protein binding
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0050689	negative regulation of defense response to virus by host
GO:0051097	negative regulation of helicase activity
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway
GO:0071357	cellular response to type I interferon
GO:0071360	cellular response to exogenous dsRNA

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P09914