InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AICDA

Summary

InnateDB Protein

IDBP-587395.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AICDA

Protein Name

activation-induced cytidine deaminase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000445691

InnateDB Gene

IDBG-17253 (AICDA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	66 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process

GO:0006397	mRNA processing
GO:0016445	somatic diversification of immunoglobulins
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0030183	B cell differentiation
GO:0080111	DNA demethylation
GO:0090310	negative regulation of methylation-dependent chromatin silencing