InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AICDA

Summary

InnateDB Gene

IDBG-17253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AICDA

Gene Name

activation-induced cytidine deaminase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000111732

Encoded Proteins

IDBP-17255

activation-induced cytidine deaminase

IDBP-598399

activation-induced cytidine deaminase

IDBP-599042

activation-induced cytidine deaminase

IDBP-587395

activation-induced cytidine deaminase

IDBP-590876

activation-induced cytidine deaminase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24244169

Kaposi's sarcoma-associated herpesvirus (KSHV) infection results in upregulation of AICDA in primary human tonsillar B cells. Two KSHV miRNAs, K12-11 and K12-5 interact with the 3�?�UTR of AICDA to translationally repress its expression.

Entrez Gene

Summary

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:8602166-8612871

Strand

Reverse strand

Band

p13.31

Transcripts

ENST00000229335	ENSP00000229335
ENST00000543081	ENSP00000439103
ENST00000544516	ENSP00000439538
ENST00000545576
ENST00000537228	ENSP00000445691
ENST00000545512	ENSP00000443060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	66 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	2 [view]
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Biological Process

GO:0006397	mRNA processing
GO:0009972	cytidine deamination
GO:0016445	somatic diversification of immunoglobulins
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0030183	B cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045190	isotype switching
GO:0071222	cellular response to lipopolysaccharide
GO:0080111	DNA demethylation
GO:0090310	negative regulation of methylation-dependent chromatin silencing

Cellular Component

GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040627

View Gene Order

ENSBTAG00000018849

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05340

Primary immunodeficiency pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

INOH website

Pyrimidine nucleotides nucleosides metabolism pathway

PID NCI

il4_2pathway

IL4-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.149342 Hs.610125 Hs.649749

RefSeq

NM_020661

HUGO

OMIM

CCDS

CCDS41747

HPRD

05585

IMGT

EMBL

GenPept

RNA Seq Atlas