InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYT5

Summary

InnateDB Protein

IDBP-587447.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT5

Protein Name

synaptotagmin V

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000442896

InnateDB Gene

IDBG-70282 (SYT5)

Protein Structure

UniProt Annotation

Function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In mast cells, localizes to the endocytic recycling compartment. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007268	synaptic transmission
GO:0017156	calcium ion-dependent exocytosis
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0055038	recycling endosome membrane