Version 5.4
Homo sapiens Gene: SYT5
Summary
InnateDB Gene IDBG-70282.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT5
Gene Name synaptotagmin V
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129990
Encoded Proteins
IDBP-70284
synaptotagmin V
IDBP-587447
synaptotagmin V
IDBP-764675
IDBP-765270
IDBP-765452
IDBP-763100
IDBP-764986
IDBP-765357
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55171199-55180441
Strand Reverse strand
Band q13.42
Transcripts
ENST00000354308 ENSP00000346265
ENST00000537500 ENSP00000442896
ENST00000587067 ENSP00000465304
ENST00000590859 ENSP00000469874
ENST00000592470 ENSP00000465110
ENST00000585461 ENSP00000465074
ENST00000589172 ENSP00000467685
ENST00000590851 ENSP00000465576
ENST00000592935
ENST00000588305
ENST00000592956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019905 syntaxin binding
GO:0030276 clathrin binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007268 synaptic transmission
GO:0017156 calcium ion-dependent exocytosis
GO:0044281 small molecule metabolic process
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0031045 dense core granule
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004961
View Gene Order
ENSBTAG00000002522
Not yet available
Pathways
NETPATH
REACTOME
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631566 Hs.635900 Hs.698371
RefSeq NM_001297774 NM_003180 XM_006723338 XM_006723339 XM_006723340 XM_006723341 XM_006723342
HUGO
OMIM
CCDS CCDS12919 CCDS74455
HPRD 02870
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca