InnateDB Protein
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IDBP-587494.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HSD17B6
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Protein Name
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hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
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Synonyms
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HSE; RODH; SDR9C6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000451406
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InnateDB Gene
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IDBG-41601 (HSD17B6)
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Protein Structure
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Function |
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. {ECO:0000269PubMed:10896656, ECO:0000269PubMed:11360992, ECO:0000269PubMed:11513953}.
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Subcellular Localization |
Microsome membrane {ECO:0000269PubMed:11360992}; Peripheral membrane protein {ECO:0000269PubMed:11360992}; Lumenal side {ECO:0000269PubMed:11360992}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. {ECO:0000269PubMed:10896656, ECO:0000269PubMed:9188497}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002198
Short-chain dehydrogenase/reductase SDR
IPR002347
Glucose/ribitol dehydrogenase
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PFAM |
PF00106
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PRINTS |
PR00080
PR00081
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PIRSF |
PIRSF000126
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O14756
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PhosphoSite |
PhosphoSite-O14756
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TrEMBL |
G3V508
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UniProt Splice Variant |
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Entrez Gene |
8630
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UniGene |
Hs.736027
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RefSeq |
XP_005269264
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HUGO |
HGNC:23316
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OMIM |
606623
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CCDS |
CCDS8925
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HPRD |
09431
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IMGT |
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EMBL |
AC117378
AC121758
AF016509
AF223225
BC020710
CH471054
U89281
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GenPept |
AAB67236
AAB88252
AAF81017
AAH20710
EAW96963
EAW96964
EAW96965
EAW96966
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