Version 5.4
Homo sapiens Gene: HSD17B6
Summary
InnateDB Gene IDBG-41601.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B6
Gene Name hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
Synonyms HSE; RODH; SDR9C6
Species Homo sapiens
Ensembl Gene ENSG00000025423
Encoded Proteins
IDBP-41603
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
IDBP-600348
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
IDBP-601187
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
IDBP-587494
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
IDBP-596510
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
IDBP-600262
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
IDBP-600816
hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist. [provided by RefSeq, Jul 2008]
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:56752161-56787790
Strand Forward strand
Band q13.3
Transcripts
ENST00000322165 ENSP00000318631
ENST00000555159 ENSP00000450698
ENST00000555805 ENSP00000451753
ENST00000554643 ENSP00000451406
ENST00000556650 ENSP00000452103
ENST00000554150 ENSP00000452273
ENST00000556481
ENST00000554155 ENSP00000451497
ENST00000556875
ENST00000553476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0004745 retinol dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0006702 androgen biosynthetic process
GO:0006710 androgen catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0031901 early endosome membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt O14756
TrEMBL A0A024RB43 G3V3Y9 G3V508
UniProt Splice Variant
Entrez Gene 8630
UniGene Hs.524513 Hs.736027
RefSeq NM_003725 XM_005269207 XM_005269208 XM_005269209 XM_006719672
HUGO HGNC:23316
OMIM 606623
CCDS CCDS8925
HPRD
IMGT
EMBL AC117378 AC121758 AF016509 AF223225 BC020710 CH471054 U89281
GenPept AAB67236 AAB88252 AAF81017 AAH20710 EAW96963 EAW96964 EAW96965 EAW96966
RNA Seq Atlas 8630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca