InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2E1

Summary

InnateDB Protein

IDBP-587648.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2E1

Protein Name

cytochrome P450, family 2, subfamily E, polypeptide 1

Synonyms

CPE1; CYP2E; P450-J; P450C2E;

Species

Homo sapiens

Ensembl Protein

ENSP00000440689

InnateDB Gene

IDBG-93837 (CYP2E1)

Protein Structure

UniProt Annotation

Function

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	16 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0010193	response to ozone
GO:0010243	response to organonitrogen compound
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0042493	response to drug
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046483	heterocycle metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0000139	Golgi membrane
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0031227	intrinsic component of endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008070 Cytochrome P450, E-class, group I, CYP2E-like

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00465
PR01687

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05181