InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPA1

Summary

InnateDB Protein

IDBP-587684.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPA1

Protein Name

heterogeneous nuclear ribonucleoprotein A1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000447260

InnateDB Gene

IDBG-37588 (HNRNPA1)

Protein Structure

UniProt Annotation

Function

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. {ECO:0000269PubMed:17229681}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.

Disease Associations

Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3) [MIM:615424]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5- 10% of the cases. {ECO:0000269PubMed:23455423}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 315 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	315 [view]
Protein-Protein	304 [view]
Protein-DNA	5 [view]
Protein-RNA	5 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0003723	RNA binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0006405	RNA export from nucleus
GO:0008219	cell death
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0051028	mRNA transport
GO:0051168	nuclear export
GO:0051170	nuclear import

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome