InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOCS2

Summary

InnateDB Protein

IDBP-587903.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS2

Protein Name

suppressor of cytokine signaling 2

Synonyms

CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000449227

InnateDB Gene

IDBG-51299 (SOCS2)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Subcellular Localization

Disease Associations

Tissue Specificity

High expression in heart, placenta, lung, kidney and prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	34 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005131	growth hormone receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005515	protein binding
GO:0008269	JAK pathway signal transduction adaptor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0007259	JAK-STAT cascade
GO:0009966	regulation of signal transduction
GO:0009967	positive regulation of signal transduction
GO:0016567	protein ubiquitination
GO:0032355	response to estradiol
GO:0032870	cellular response to hormone stimulus
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046426	negative regulation of JAK-STAT cascade
GO:0060396	growth hormone receptor signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway