Version 5.4
Homo sapiens Protein: SOCS2
Summary
InnateDB Protein IDBP-587981.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS2
Protein Name suppressor of cytokine signaling 2
Synonyms CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2;
Species Homo sapiens
Ensembl Protein ENSP00000447902
InnateDB Gene IDBG-51299 (SOCS2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005159 insulin-like growth factor receptor binding
GO:0008269 JAK pathway signal transduction adaptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0046426 negative regulation of JAK-STAT cascade
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F8VU91
UniProt Splice Variant
Entrez Gene 8835
UniGene Hs.738912
RefSeq
HUGO HGNC:19382
OMIM 605117
CCDS
HPRD 05490
IMGT
EMBL AC012085
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca