InnateDB Protein
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IDBP-588148.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLEC4C
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Protein Name
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C-type lectin domain family 4, member C
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000445338
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InnateDB Gene
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IDBG-16472 (CLEC4C)
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Protein Structure
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Function |
Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein- tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. {ECO:0000269PubMed:11031109, ECO:0000269PubMed:11748283}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. {ECO:0000269PubMed:11031109, ECO:0000269PubMed:11536172, ECO:0000269PubMed:11748283}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR002353
Type-2 ice-structuring protein
IPR016187
C-type lectin fold
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PFAM |
PF00059
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PRINTS |
PR00356
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WTT0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
H0YFH6
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UniProt Splice Variant |
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Entrez Gene |
170482
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UniGene |
Hs.351812
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RefSeq |
NP_987099
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HUGO |
HGNC:13258
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OMIM |
606677
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CCDS |
CCDS8584
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HPRD |
09453
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IMGT |
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EMBL |
AC006517
AF293615
AF325459
AF325460
AY358223
BC074967
BC074968
BC102015
BC102016
BC102017
BC114338
CH471116
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GenPept |
AAH74967
AAH74968
AAI02016
AAI02017
AAI02018
AAI14339
AAL37036
AAL37358
AAL37359
AAQ88590
EAW88655
EAW88656
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