InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLIRP

Summary

InnateDB Protein

IDBP-588251.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLIRP

Protein Name

SRA stem-loop interacting RNA binding protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000450909

InnateDB Gene

IDBG-14081 (SLIRP)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. {ECO:0000269PubMed:16762838}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:16762838}. Nucleus {ECO:0000269PubMed:16762838}. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis. {ECO:0000269PubMed:16762838}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000961	negative regulation of mitochondrial RNA catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007286	spermatid development
GO:0007338	single fertilization
GO:0030317	sperm motility
GO:0070584	mitochondrion morphogenesis

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0030529	ribonucleoprotein complex
GO:0036126	sperm flagellum
GO:0048471	perinuclear region of cytoplasm