InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VTI1B

Summary

InnateDB Protein

IDBP-588325.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VTI1B

Protein Name

vesicle transport through interaction with t-SNAREs homolog 1B (yeast)

Synonyms

v-SNARE; VTI1; VTI1-LIKE; vti1-rp1; VTI1L; VTI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000450731

InnateDB Gene

IDBG-9964 (VTI1B)

Protein Structure

UniProt Annotation

Function

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

Subcellular Localization

Late endosome membrane {ECO:0000269PubMed:23217709}; Single-pass type IV membrane protein {ECO:0000269PubMed:23217709}. Lysosome membrane {ECO:0000269PubMed:23217709}. Cytoplasmic granule {ECO:0000269PubMed:23217709}.

Disease Associations

Tissue Specificity

Expressed in all tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006904	vesicle docking involved in exocytosis
GO:0008283	cell proliferation
GO:0016192	vesicle-mediated transport
GO:0061025	membrane fusion

Cellular Component

GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031201	SNARE complex
GO:0031902	late endosome membrane
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm