Version 5.4
Homo sapiens Protein: ABR
Summary
InnateDB Protein IDBP-588344.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABR
Protein Name active BCR-related gene
Synonyms MDB;
Species Homo sapiens
Ensembl Protein ENSP00000445198
InnateDB Gene IDBG-14430 (ABR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PRINTS
PIRSF
SMART SM00324
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12979
PhosphoSite PhosphoSite-Q12979
TrEMBL
UniProt Splice Variant
Entrez Gene 29
UniGene Hs.742468
RefSeq NP_001243776
HUGO HGNC:81
OMIM 600365
CCDS CCDS58497
HPRD 02649
IMGT
EMBL AC015884 AC016292 AC144836 AK124547 AK300336 CH471108 L19704 L19705 U01147
GenPept AAC37518 AAC37519 AAC50063 BAG54051 BAH13263 EAW90631 EAW90633 EAW90634 EAW90635

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca