Version 5.4
Homo sapiens Protein: HMGB3
Summary
InnateDB Protein IDBP-588554.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HMGB3
Protein Name high mobility group box 3
Synonyms HMG-2a; HMG-4; HMG2A; HMG4;
Species Homo sapiens
Ensembl Protein ENSP00000442758
InnateDB Gene IDBG-88858 (HMGB3)
Protein Structure
UniProt Annotation
Function Binds preferentially single-stranded DNA and unwinds double-stranded DNA. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed predominantly in placenta.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0008301 DNA binding, bending
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006310 DNA recombination
GO:0007275 multicellular organismal development
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
PFAM PF00505
PF09011
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15347
PhosphoSite PhosphoSite-O15347
TrEMBL E9PES6
UniProt Splice Variant
Entrez Gene 3149
UniGene Hs.595140
RefSeq
HUGO HGNC:5004
OMIM 300193
CCDS CCDS35428
HPRD 02181
IMGT
EMBL AF003626 BC070482 Y10043
GenPept AAH70482 CAA71143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca