Homo sapiens Protein: HTR3B | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-588682.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | HTR3B | ||||||||||||
Protein Name | 5-hydroxytryptamine (serotonin) receptor 3B | ||||||||||||
Synonyms | 5-HT3B; | ||||||||||||
Species | Homo sapiens | ||||||||||||
Ensembl Protein | ENSP00000443118 | ||||||||||||
InnateDB Gene | IDBG-71881 (HTR3B) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269PubMed:12867984}. | ||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:21138434}; Multi-pass membrane protein {ECO:0000269PubMed:21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta. {ECO:0000269PubMed:10521471, ECO:0000269PubMed:9950429}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR006029
Neurotransmitter-gated ion-channel transmembrane domain IPR006201 Neurotransmitter-gated ion-channel IPR006202 Neurotransmitter-gated ion-channel ligand-binding IPR008132 5-hydroxytryptamine 3 receptor IPR008133 5-hydroxytryptamine 3 receptor, A subunit IPR008134 5-hydroxytryptamine 3 receptor, B subunit |
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PFAM |
PF02932
PF02931 |
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PRINTS |
PR00252
PR01708 PR01709 PR01710 |
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PIRSF | |||||||||||||
SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | O95264 | ||||||||||||
PhosphoSite | PhosphoSite-O95264 | ||||||||||||
TrEMBL | B3VRP0 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 9177 | ||||||||||||
UniGene | Hs.241377 | ||||||||||||
RefSeq | |||||||||||||
HUGO | HGNC:5298 | ||||||||||||
OMIM | 604654 | ||||||||||||
CCDS | |||||||||||||
HPRD | 06875 | ||||||||||||
IMGT | |||||||||||||
EMBL | AF080582 AF169255 AK314268 AM293589 EF444985 EU796519 EU796524 EU796529 EU796534 EU796544 EU796554 | ||||||||||||
GenPept | AAD12242 AAF03691 ACA06001 ACE96228 ACE96238 ACE96248 ACE96253 ACE96258 ACE96263 BAG36930 CAL25321 | ||||||||||||