Version 5.4
Homo sapiens Gene: HTR3B
Summary
InnateDB Gene IDBG-71881.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTR3B
Gene Name 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
Synonyms 5-HT3B
Species Homo sapiens
Ensembl Gene ENSG00000149305
Encoded Proteins
IDBP-71883
5-hydroxytryptamine (serotonin) receptor 3B
IDBP-588682
5-hydroxytryptamine (serotonin) receptor 3B
IDBP-588068
5-hydroxytryptamine (serotonin) receptor 3B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:113904677-113946565
Strand Forward strand
Band q23.2
Transcripts
ENST00000260191 ENSP00000260191
ENST00000537778 ENSP00000443118
ENST00000543092 ENSP00000440894
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004993 serotonin receptor activity
GO:0005216 ion channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005232 serotonin-activated cation-selective channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007210 serotonin receptor signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008590
View Gene Order
ENSBTAG00000031330
Not yet available
Pathways
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O95264
TrEMBL B3VRK5 B3VRL0 B3VRL5 B3VRM0 B3VRN0 B3VRP0
UniProt Splice Variant
Entrez Gene 9177
UniGene Hs.241377
RefSeq NM_006028
HUGO HGNC:5298
OMIM 604654
CCDS CCDS8364
HPRD 06875
IMGT
EMBL AF080582 AF169255 AK314268 AM293589 EF444985 EU796519 EU796524 EU796529 EU796534 EU796544 EU796554
GenPept AAD12242 AAF03691 ACA06001 ACE96228 ACE96238 ACE96248 ACE96253 ACE96258 ACE96263 BAG36930 CAL25321
RNA Seq Atlas 9177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca