InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRMS1

Summary

InnateDB Protein

IDBP-58885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRMS1

Protein Name

breast cancer metastasis suppressor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353042

InnateDB Gene

IDBG-58883 (BRMS1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269PubMed:14581478, ECO:0000269PubMed:17000776, ECO:0000269PubMed:20830743}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Disease Associations

Tissue Specificity

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. {ECO:0000269PubMed:12414911}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090312	positive regulation of protein deacetylation
GO:2000210	positive regulation of anoikis