InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAF2

Summary

InnateDB Protein

IDBP-58897.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAF2

Protein Name

Fas associated factor family member 2

Synonyms

ETEA; UBXD8; UBXN3B;

Species

Homo sapiens

Ensembl Protein

ENSP00000261942

InnateDB Gene

IDBG-58895 (FAF2)

Protein Structure

UniProt Annotation

Function

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. {ECO:0000269PubMed:18711132}.

Subcellular Localization

Cytoplasm. Lipid droplet. Endoplasmic reticulum.

Disease Associations

Tissue Specificity

Broadly expressed, with highest levels in brain. {ECO:0000269PubMed:12372427}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.

Experimentally validated
Total	84 [view]
Protein-Protein	84 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0035473	lipase binding
GO:0043130	ubiquitin binding
GO:0055102	lipase inhibitor activity

Biological Process

GO:0006986	response to unfolded protein
GO:0034389	lipid particle organization
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005811	lipid particle
GO:0034098	Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0043231	intracellular membrane-bounded organelle