InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LDLR

Summary

InnateDB Protein

IDBP-589029.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LDLR

Protein Name

low density lipoprotein receptor

Synonyms

FH; FHC; LDLCQ2;

Species

Homo sapiens

Ensembl Protein

ENSP00000453346

InnateDB Gene

IDBG-28808 (LDLR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005041	low-density lipoprotein receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030229	very-low-density lipoprotein particle receptor activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006629	lipid metabolic process
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007603	phototransduction, visible light
GO:0010867	positive regulation of triglyceride biosynthetic process
GO:0010899	regulation of phosphatidylcholine catabolic process
GO:0015914	phospholipid transport
GO:0016032	viral process
GO:0030299	intestinal cholesterol absorption
GO:0030301	cholesterol transport
GO:0034383	low-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0044281	small molecule metabolic process
GO:0070508	cholesterol import

Cellular Component

GO:0005764	lysosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005905	coated pit
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0034362	low-density lipoprotein particle
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat

PFAM

PF00058
PF00008
PF07645
PF00057

PRINTS

PR00261

PIRSF

SMART

SM00135
SM00181
SM00179
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt