Version 5.4
Homo sapiens Protein: DACT3
Summary
InnateDB Protein IDBP-58903.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DACT3
Protein Name dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000300875
InnateDB Gene IDBG-58901 (DACT3)
Protein Structure
UniProt Annotation
Function May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. {ECO:0000269PubMed:18538736}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0051018 protein kinase A binding
GO:0070097 delta-catenin binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0035414 negative regulation of catenin import into nucleus
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96B18
PhosphoSite PhosphoSite-Q96B18
TrEMBL
UniProt Splice Variant
Entrez Gene 147906
UniGene Hs.515490
RefSeq NP_001287975
HUGO HGNC:30745
OMIM 611112
CCDS CCDS74402
HPRD 17505
IMGT
EMBL BC016161 BI603646
GenPept AAH16161

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca