InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESPL1

Summary

InnateDB Protein

IDBP-589090.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESPL1

Protein Name

extra spindle pole bodies homolog 1 (S. cerevisiae)

Synonyms

ESP1; SEPA;

Species

Homo sapiens

Ensembl Protein

ENSP00000449831

InnateDB Gene

IDBG-36272 (ESPL1)

Protein Structure

UniProt Annotation

Function

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269PubMed:10411507, ECO:0000269PubMed:11509732}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0040001	establishment of mitotic spindle localization
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0045875	negative regulation of sister chromatid cohesion