InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRMT2B

Summary

InnateDB Protein

IDBP-589113.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRMT2B

Protein Name

TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000438134

InnateDB Gene

IDBG-79408 (TRMT2B)

Protein Structure

UniProt Annotation

Function

Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008173	RNA methyltransferase activity
GO:0030697	S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity

Biological Process

GO:0006396	RNA processing
GO:0008033	tRNA processing
GO:0032259	methylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR007848 Methyltransferase small domain
IPR010280 (Uracil-5)-methyltransferase family
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF05175
PF05958

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96GJ1

PhosphoSite