Version 5.4
Homo sapiens Gene: TRMT2B
Summary
InnateDB Gene IDBG-79408.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRMT2B
Gene Name tRNA methyltransferase 2 homolog B (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000188917
Encoded Proteins
IDBP-79414
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
IDBP-79416
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
IDBP-79418
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
IDBP-589113
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:101009346-101052116
Strand Reverse strand
Band q22.1
Transcripts
ENST00000372939 ENSP00000362030
ENST00000372936 ENSP00000362027
ENST00000372935 ENSP00000362026
ENST00000478422
ENST00000488615
ENST00000545398 ENSP00000438134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000067369
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496501
RefSeq NM_001167970 NM_001167971 NM_001167972 NM_024917 XM_005262196 XM_006724707
HUGO
OMIM
CCDS CCDS14477 CCDS55464
HPRD 06520
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca