Version 5.4
Homo sapiens Protein: TAGLN
Summary
InnateDB Protein IDBP-589129.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAGLN
Protein Name transgelin
Synonyms SM22; SMCC; TAGLN1; WS3-10;
Species Homo sapiens
Ensembl Protein ENSP00000432282
InnateDB Gene IDBG-73062 (TAGLN)
Protein Structure
UniProt Annotation
Function Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007517 muscle organ development
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000557 Calponin repeat
IPR001715 Calponin homology domain
IPR003096 Smooth muscle protein/calponin
PFAM PF00402
PF00307
PRINTS PR00888
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q01995
PhosphoSite PhosphoSite-Q01995
TrEMBL Q5U0D2
UniProt Splice Variant
Entrez Gene 6876
UniGene Hs.410977
RefSeq
HUGO HGNC:11553
OMIM 600818
CCDS CCDS8381
HPRD 02891
IMGT
EMBL AF013711 AK314043 AP000892 AP005018 BC004927 BC065829 BC092415 BC093050 BT019648 BT019649 CH471065 CR541681 CR749612 D17409 D84342 EF445034 M83106 M95787
GenPept AAA58351 AAA58375 AAC21582 AAH04927 AAH65829 AAH92415 AAH93050 AAV38454 AAV38455 ACA06080 BAA21811 BAA21839 BAG36752 CAG46482 CAH18406 EAW67299 EAW67301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca