Version 5.4
Homo sapiens Gene: TAGLN
Summary
InnateDB Gene IDBG-73062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAGLN
Gene Name transgelin
Synonyms SM22; SMCC; TAGLN1; WS3-10
Species Homo sapiens
Ensembl Gene ENSG00000149591
Encoded Proteins
IDBP-73064
transgelin
IDBP-244614
transgelin
IDBP-584801
transgelin
IDBP-597973
transgelin
IDBP-600081
transgelin
IDBP-589129
transgelin
IDBP-595072
transgelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117199321-117204782
Strand Forward strand
Band q23.3
Transcripts
ENST00000278968 ENSP00000278968
ENST00000392951 ENSP00000376678
ENST00000525531 ENSP00000432054
ENST00000529792 ENSP00000431862
ENST00000533863
ENST00000530649 ENSP00000431941
ENST00000532870 ENSP00000432282
ENST00000529622 ENSP00000432380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0007517 muscle organ development
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032085
View Gene Order
ENSBTAG00000007196
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt Q01995
TrEMBL E9PJ32 Q5U0D2
UniProt Splice Variant
Entrez Gene 6876
UniGene Hs.410977
RefSeq NM_001001522 NM_003186
HUGO HGNC:11553
OMIM 600818
CCDS CCDS8381
HPRD 02891
IMGT
EMBL AF013711 AK314043 AP000892 AP005018 BC004927 BC065829 BC092415 BC093050 BT019648 BT019649 CH471065 CR541681 CR749612 D17409 D84342 EF445034 M83106 M95787
GenPept AAA58351 AAA58375 AAC21582 AAH04927 AAH65829 AAH92415 AAH93050 AAV38454 AAV38455 ACA06080 BAA21811 BAA21839 BAG36752 CAG46482 CAH18406 EAW67299 EAW67301
RNA Seq Atlas 6876

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca