InnateDB Protein
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IDBP-589262.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYTL2
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Protein Name
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synaptotagmin-like 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432996
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InnateDB Gene
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IDBG-66497 (SYTL2)
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Protein Structure
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Function |
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269PubMed:17182843, ECO:0000269PubMed:18266782, ECO:0000269PubMed:18812475}.
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Subcellular Localization |
Isoform 1: Cytoplasm. Cell membrane. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.Isoform 4: Cell membrane. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. {ECO:0000269PubMed:17182843, ECO:0000269PubMed:18266782, ECO:0000269PubMed:18812475}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000008
C2 domain
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PFAM |
PF00168
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PRINTS |
PR00360
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HCH5
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PhosphoSite |
PhosphoSite-Q9HCH5
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TrEMBL |
Q9BQS1
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UniProt Splice Variant |
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Entrez Gene |
54843
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UniGene |
Hs.596233
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RefSeq |
NP_115755
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HUGO |
HGNC:15585
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OMIM |
612880
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CCDS |
CCDS31652
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HPRD |
10260
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IMGT |
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EMBL |
AB046817
AJ303364
AK000170
AK024872
AK074737
AK092121
AK124754
AK127504
AK131365
AK296224
AK296740
AK298604
AL834422
AP000642
AP000974
AY386362
BC015540
BC110315
BC136450
BC144114
BC144115
CH471076
EU035829
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GenPept |
AAH15540
AAI10316
AAI36451
AAI44115
AAI44116
AAR25619
ABV82746
BAA90989
BAB13423
BAB15030
BAC11170
BAC85937
BAD18516
BAG52485
BAG58947
BAG59325
BAG60788
CAC33886
CAD39083
EAW75108
EAW75110
EAW75113
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