Version 5.4
Homo sapiens Gene: SYTL2
Summary
InnateDB Gene IDBG-66497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYTL2
Gene Name synaptotagmin-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137501
Encoded Proteins
IDBP-66499
synaptotagmin-like 2
IDBP-66503
synaptotagmin-like 2
IDBP-66507
synaptotagmin-like 2
IDBP-66513
synaptotagmin-like 2
IDBP-586191
synaptotagmin-like 2
IDBP-589262
synaptotagmin-like 2
IDBP-589393
synaptotagmin-like 2
IDBP-592377
synaptotagmin-like 2
IDBP-586994
synaptotagmin-like 2
IDBP-602600
synaptotagmin-like 2
IDBP-589640
synaptotagmin-like 2
IDBP-589019
synaptotagmin-like 2
IDBP-597219
synaptotagmin-like 2
IDBP-594346
synaptotagmin-like 2
IDBP-593619
synaptotagmin-like 2
IDBP-591502
synaptotagmin-like 2
IDBP-586823
synaptotagmin-like 2
IDBP-603258
synaptotagmin-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:85694224-85811159
Strand Reverse strand
Band q14.1
Transcripts
ENST00000316356 ENSP00000318803
ENST00000354566
ENST00000359152 ENSP00000352065
ENST00000389960 ENSP00000374610
ENST00000389959
ENST00000389958 ENSP00000374608
ENST00000438197
ENST00000532995 ENSP00000436678
ENST00000525702 ENSP00000432996
ENST00000525423
ENST00000529581 ENSP00000435855
ENST00000530351
ENST00000528231 ENSP00000431701
ENST00000531496
ENST00000525692
ENST00000533892 ENSP00000432144
ENST00000527523 ENSP00000434010
ENST00000524452 ENSP00000435238
ENST00000529662
ENST00000533057 ENSP00000436164
ENST00000527794 ENSP00000437005
ENST00000529534 ENSP00000432137
ENST00000530894
ENST00000526999 ENSP00000434111
ENST00000532221 ENSP00000431703
ENST00000524911 ENSP00000432116
ENST00000533577 ENSP00000434621
ENST00000534554
ENST00000528566
ENST00000524830
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0017137 Rab GTPase binding
GO:0019902 phosphatase binding
GO:0042043 neurexin family protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0010923 negative regulation of phosphatase activity
GO:0016192 vesicle-mediated transport
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0042470 melanosome
GO:0070382 exocytic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030616
View Gene Order
ENSBTAG00000000460
Not yet available
Cross-References
SwissProt
TrEMBL E9PK22 E9PS39
UniProt Splice Variant
Entrez Gene 54843
UniGene Hs.369520 Hs.596233
RefSeq NM_001162951 NM_001162952 NM_001162953 NM_001289608 NM_001289609 NM_001289610 NM_032379 NM_032943 NM_206929 NM_206930 XM_005274060 XM_005274061 XM_005274063 XM_005274067 XM_006718590
HUGO HGNC:15585
OMIM 612880
CCDS CCDS31649 CCDS31652 CCDS41698 CCDS53687 CCDS53688 CCDS53689
HPRD 10260
IMGT
EMBL AP000642 AP000974
GenPept
RNA Seq Atlas 54843

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca