Version 5.4
Homo sapiens Protein: RAET1E
Summary
InnateDB Protein IDBP-589442.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAET1E
Protein Name retinoic acid early transcript 1E
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000437067
InnateDB Gene IDBG-97825 (RAET1E)
Protein Structure
UniProt Annotation
Function Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.
Subcellular Localization Membrane; Single-pass type I membrane protein.Isoform RAET1E2: Secreted.
Disease Associations
Tissue Specificity Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. {ECO:0000269PubMed:12732206, ECO:0000269PubMed:14508119}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0046703 natural killer cell lectin-like receptor binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR011162 MHC classes I/II-like antigen recognition protein
PFAM PF00129
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TD07
PhosphoSite PhosphoSite-
TrEMBL I2GUA6
UniProt Splice Variant
Entrez Gene 135250
UniGene Hs.511818
RefSeq NP_001230257
HUGO HGNC:16793
OMIM 609243
CCDS CCDS59043
HPRD 16466
IMGT
EMBL AF359243 AL355312 AY054974 AY069961 AY176317 AY252119 AY359075 EF489426 HE806192 JX051316
GenPept AAL11005 AAL58090 AAL76417 AAO22240 AAP15166 AAQ89434 ABR29881 AFP19435 CAH72868 CAH72869 CCH57707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca