Version 5.4
Homo sapiens Protein: SLC29A2
Summary
InnateDB Protein IDBP-58946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC29A2
Protein Name solute carrier family 29 (nucleoside transporters), member 2
Synonyms DER12; ENT2; HNP36;
Species Homo sapiens
Ensembl Protein ENSP00000350024
InnateDB Gene IDBG-58944 (SLC29A2)
Protein Structure
UniProt Annotation
Function Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269PubMed:9396714}.
Subcellular Localization Basolateral cell membrane {ECO:0000269PubMed:12527552}; Multi-pass membrane protein {ECO:0000269PubMed:12527552}. Nucleus membrane {ECO:0000269PubMed:12527552}; Multi-pass membrane protein {ECO:0000269PubMed:12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. {ECO:0000269PubMed:12527552, ECO:0000269PubMed:9396714}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005337 nucleoside transmembrane transporter activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006810 transport
GO:0008283 cell proliferation
GO:0015858 nucleoside transport
GO:0055085 transmembrane transport
GO:1901642 nucleoside transmembrane transport
Cellular Component
GO:0005730 nucleolus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR002259 Equilibrative nucleoside transporter
IPR016196 Major facilitator superfamily domain, general substrate transporter
PFAM PF01733
PRINTS PR01130
PIRSF PIRSF016379
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14542
PhosphoSite PhosphoSite-Q14542
TrEMBL
UniProt Splice Variant
Entrez Gene 3177
UniGene
RefSeq NP_001523
HUGO HGNC:11004
OMIM 602110
CCDS CCDS8137
HPRD 03662
IMGT
EMBL AF029358 AF034102 AF401235 AK057041 AP001107 BC093634 CH471076 X86681
GenPept AAB97834 AAC39526 AAH93634 AAK92533 BAG51849 CAA60380 EAW74519 EAW74521

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca