Version 5.4
Homo sapiens Protein: CDHR2
Summary
InnateDB Protein IDBP-58958.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDHR2
Protein Name cadherin-related family member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261944
InnateDB Gene IDBG-58956 (CDHR2)
Protein Structure
UniProt Annotation
Function Role in contact inhibition at the lateral surface of epithelial cells. {ECO:0000269PubMed:12117771}.
Subcellular Localization Apical cell membrane {ECO:0000269PubMed:12117771}; Single-pass type I membrane protein {ECO:0000269PubMed:12117771}. Cell junction {ECO:0000269PubMed:12117771}. Note=Present at the cell junctions and the apical surface of cells. Colocalizes with actin at the microvilli-like structures which protrude from the apical surface.
Disease Associations
Tissue Specificity Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers. {ECO:0000269PubMed:12117771, ECO:0000269PubMed:15534908}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0030308 negative regulation of cell growth
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002126 Cadherin
IPR015919 Cadherin-like
PFAM PF00028
PRINTS PR00205
PIRSF
SMART SM00112
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYE9
PhosphoSite PhosphoSite-Q9BYE9
TrEMBL
UniProt Splice Variant
Entrez Gene 54825
UniGene Hs.4205
RefSeq NP_060145
HUGO HGNC:18231
OMIM
CCDS CCDS34297
HPRD 15103
IMGT
EMBL AB047004 AC091934 AK000131 AK315055 BC130282
GenPept AAI30283 BAA90962 BAB40777 BAG37531

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca