InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUT

Summary

InnateDB Protein

IDBP-589672.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUT

Protein Name

deoxyuridine triphosphatase

Synonyms

dUTPase;

Species

Homo sapiens

Ensembl Protein

ENSP00000453717

InnateDB Gene

IDBG-10926 (DUT)

Protein Structure

UniProt Annotation

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. {ECO:0000269PubMed:8805593}.

Subcellular Localization

Isoform 2: Nucleus.Isoform 3: Mitochondrion.

Disease Associations

Tissue Specificity

Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). {ECO:0000269PubMed:9228092}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004170	dUTP diphosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006206	pyrimidine nucleobase metabolic process
GO:0006226	dUMP biosynthetic process
GO:0006260	DNA replication
GO:0044281	small molecule metabolic process
GO:0046080	dUTP metabolic process
GO:0046134	pyrimidine nucleoside biosynthetic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR008180 Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase
IPR008181 Deoxyuridine triphosphate nucleotidohydrolase
IPR029054 dUTPase-like

PFAM

PF00692

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33316

PhosphoSite