InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADM

Summary

InnateDB Protein

IDBP-589740.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADM

Protein Name

adrenomedullin

Synonyms

AM; PAMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000436607

InnateDB Gene

IDBG-31636 (ADM)

Protein Structure

UniProt Annotation

Function

AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0031700	adrenomedullin receptor binding

Biological Process

GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001843	neural tube closure
GO:0002026	regulation of the force of heart contraction
GO:0002031	G-protein coupled receptor internalization
GO:0006171	cAMP biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007568	aging
GO:0008015	blood circulation
GO:0008209	androgen metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009409	response to cold
GO:0009611	response to wounding
GO:0010033	response to organic substance
GO:0010460	positive regulation of heart rate
GO:0019933	cAMP-mediated signaling
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031100	organ regeneration
GO:0031102	neuron projection regeneration
GO:0031623	receptor internalization
GO:0032496	response to lipopolysaccharide
GO:0032868	response to insulin
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042594	response to starvation
GO:0043065	positive regulation of apoptotic process
GO:0043116	negative regulation of vascular permeability
GO:0045766	positive regulation of angiogenesis
GO:0045906	negative regulation of vasoconstriction
GO:0045909	positive regulation of vasodilation
GO:0046879	hormone secretion
GO:0048589	developmental growth
GO:0051384	response to glucocorticoid
GO:0055074	calcium ion homeostasis
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060712	spongiotrophoblast layer development
GO:0097084	vascular smooth muscle cell development
GO:2001214	positive regulation of vasculogenesis