Version 5.4
Homo sapiens Gene: ADM
Summary
InnateDB Gene IDBG-31636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADM
Gene Name adrenomedullin
Synonyms AM; PAMP
Species Homo sapiens
Ensembl Gene ENSG00000148926
Encoded Proteins
IDBP-31638
adrenomedullin
IDBP-601972
adrenomedullin
IDBP-598878
adrenomedullin
IDBP-604027
adrenomedullin
IDBP-589740
adrenomedullin
IDBP-602127
adrenomedullin
IDBP-584340
adrenomedullin
IDBP-603446
adrenomedullin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of 4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:10304680-10307397
Strand Forward strand
Band p15.4
Transcripts
ENST00000278175 ENSP00000278175
ENST00000534464 ENSP00000431438
ENST00000530439 ENSP00000436837
ENST00000524948 ENSP00000433062
ENST00000528655 ENSP00000436607
ENST00000526492 ENSP00000434354
ENST00000525063 ENSP00000435124
ENST00000528544 ENSP00000434749
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031700 adrenomedullin receptor binding
Biological Process
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001843 neural tube closure
GO:0002026 regulation of the force of heart contraction
GO:0002031 G-protein coupled receptor internalization
GO:0006171 cAMP biosynthetic process
GO:0006701 progesterone biosynthetic process
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008015 blood circulation
GO:0008209 androgen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009611 response to wounding
GO:0010033 response to organic substance
GO:0010460 positive regulation of heart rate
GO:0019933 cAMP-mediated signaling
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031100 organ regeneration
GO:0031102 neuron projection regeneration
GO:0031623 receptor internalization
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0045906 negative regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0046879 hormone secretion
GO:0048589 developmental growth
GO:0051384 response to glucocorticoid
GO:0055074 calcium ion homeostasis
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060712 spongiotrophoblast layer development
GO:0097084 vascular smooth muscle cell development
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030790
View Gene Order
ENSBTAG00000021048
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18290
Calcitonin-like ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.441047
RefSeq NM_001124
HUGO
OMIM
CCDS CCDS7801
HPRD 00061
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca