InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPLA

Summary

InnateDB Protein

IDBP-58990.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPLA

Protein Name

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

Synonyms

CAP; HACD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000355308

InnateDB Gene

IDBG-58986 (PTPLA)

Protein Structure

UniProt Annotation

Function

Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. {ECO:0000269PubMed:18554506}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:18554506}; Multi-pass membrane protein {ECO:0000269PubMed:18554506}.

Disease Associations

Tissue Specificity

Highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. {ECO:0000269PubMed:11054553, ECO:0000269PubMed:18554506}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0016829	lyase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0014902	myotube differentiation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:2000045	regulation of G1/S transition of mitotic cell cycle