Version 5.4
Homo sapiens Gene: PTPLA
Summary
InnateDB Gene IDBG-58986.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPLA
Gene Name protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
Synonyms CAP; HACD1
Species Homo sapiens
Ensembl Gene ENSG00000165996
Encoded Proteins
IDBP-58990
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
IDBP-58992
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
IDBP-748979
IDBP-749081
IDBP-811902
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:17589032-17617377
Strand Reverse strand
Band p12.33
Transcripts
ENST00000361271 ENSP00000355308
ENST00000326961 ENSP00000322923
ENST00000498812 ENSP00000462868
ENST00000471481
ENST00000466335 ENSP00000462336
ENST00000618390 ENSP00000484550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0016829 lyase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0014902 myotube differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063275
View Gene Order
ENSBTAG00000033089
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa00062
Fatty acid elongation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6NP58
UniProt Splice Variant
Entrez Gene 9200
UniGene
RefSeq NM_014241 XM_006717536
HUGO HGNC:9639
OMIM 610467
CCDS CCDS7121
HPRD 10175
IMGT
EMBL AC069542
GenPept
RNA Seq Atlas 9200

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca