InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SORT1

Summary

InnateDB Protein

IDBP-589919.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SORT1

Protein Name

sortilin 1

Synonyms

Gp95; LDLCQ6; NT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000438597

InnateDB Gene

IDBG-100814 (SORT1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0010465	nerve growth factor receptor activity
GO:0019899	enzyme binding
GO:0030379	neurotensin receptor activity, non-G-protein coupled
GO:0048406	nerve growth factor binding

Biological Process

GO:0001503	ossification
GO:0006895	Golgi to endosome transport
GO:0006897	endocytosis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007275	multicellular organismal development
GO:0008333	endosome to lysosome transport
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010468	regulation of gene expression
GO:0014902	myotube differentiation
GO:0016050	vesicle organization
GO:0032509	endosome transport via multivesicular body sorting pathway
GO:0032868	response to insulin
GO:0038180	nerve growth factor signaling pathway
GO:0046323	glucose import
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048227	plasma membrane to endosome transport
GO:0051005	negative regulation of lipoprotein lipase activity

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030136	clathrin-coated vesicle
GO:0031965	nuclear membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm